The following information includes only the average doses of this medicine. -Following initiation and/or upon titration, lipid levels should be evaluated within 2 to 4 weeks and dosages adjusted accordingly. Effects of synvinolin (MK-733) on plasma lipids in familial hypercholesterolaemia. -Individualize dose based on goals of therapy and response -An initial dose of 40 mg may be used in patients who require a larger reduction in low density lipoprotein (e.g. -In patients with multiple risk factors for coronary heart disease (CHD) such as smoking, hypertension, low HDL-C,or a family history of early CHD, this drug is indicated to reduce the risk of/for: Myocardial infarction, stroke, revascularization procedures, and angina. However, there are certain circumstances where a doctor might feel compelled to continue with statins despite the muscle pain and weakness and that is in the case of high risk where in the doctor's judgment a lot may be riding on their use. var s = document.getElementsByTagName('script')[0]; '//cse.google.com/cse.js?cx=' + cx; -Following initiation and/or upon titration, lipid levels should be evaluated within 2 to 4 weeks and dosages adjusted accordingly. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Privacy Policy | Terms of Service | Sitemap, © This article is copyrighted and may not be reproduced in any form without written permission from spacedoc.com. CMAJ 181 (1-2). -Take orally once a day at any time, with or without food LIMIT atorvastatin dose to 20 mg/day with concomitant use of clarithromycin, itraconazole, elbasvir plus grazoprevir, or with HIV combinations of saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, or fosamprenavir plus ritonavir; appropriate clinical assessment is recommended to ensure the lowest effective dose is employed 10 years or older: 10 mg to 80 mg orally once a day -Patients should be aware that there are a number of potential drug interactions with this drug and they should speak with a healthcare professional before starting any new medications including over the counter medications. Use: To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid lowering treatment (e.g., LDL apheresis) or if such treatments are unavailable. -Dose adjustments should be made at intervals of 4 weeks or more. Maximum dose: 20 mg/day Monitoring: Uses: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Read the full Terms and Conditions, Privacy Policy and Disclaimers before using this site.Contact To contact site administrator regarding technical or other aspects of this site, e-mail to site@spacedoc.com Note that no personal medical questions of any kind can or will be answered. Why the 'Cholesterol Causes Coronary Heart Disease' Dogma has Persisted, Evidence Against Cholesterol Causing Atherosclerosis. Duane Graveline MD MPHFormer USAF Flight SurgeonFormer NASA AstronautRetired Family Doctor. Maintenance dose: 10 mg to 80 mg orally once a day If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. Atorvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood). General: Lancet 1986;2(8513):936-9. -Active liver disease or unexplained persistent elevations in serum transaminases levels -As an adjunct to diet for the treatment of patients with elevated TG levels (Fredrickson Type IV). by Duane Graveline, MD, MPHStudy after study has shown the benefit of statin drugs in reducing the incidence of heart attack and stroke for high risk people. More studies have to be done, but if a low dose statin provides a reasonable option for statin-intolerant high-risk people, why not consider it for more general use to reduce the unacceptable side effect legacy of statins? Safety and efficacy have not been established in patients younger than 10 years with HeFH (heterozygous familial hypercholesterolemia) or pre-pubertal adolescents. 2, Uffe Ravnskov - The Real Cause of Heart Disease? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. They are all inhibitors of a single reductase step in the synthesis of cholesterol and side effects from one statin are very likely to occur in the alternative as well. -This drug is indicated in pediatric patients who, despite diet therapy, have an LDL-C of 190 mg/dL or greater, or have an LDL-C of 160 mg/dL or greater with a positive family history of premature cardiovascular disease (CVD) OR 2 or more other CVD risk factors. CONTRAINDICATIONS: AVOID concomitant atorvastatin use with cyclosporine, tipranavir plus ritonavir, glecaprevir plus pibrentasvir Is alternate daily dose of atorvastatineffective in treating patients with hyperlipidemia? Statins appear to work by another mechanism, some researchers now say, relieving inflammation in the endothelial lining of blood vessels - this reduces sclerotic change. Today it is almost standard that the starting dose be at least 20 to 40 mg, of atorvastatin (Lipitor®) or simvastatin (Zocor®) - or its equivalent in the other statins.With the incidence of statin-associated myopathy (by some estimates at 12-15% (Ref. The concentration of LDL cholesterol was 24 mg/dL lower in those taking the higher dose of atorvastatin… Recommendations, statements and other opinions expressed on this site have not been evaluated by the U.S. Food and Drug Administration. The focus on cholesterol as the culprit has led to higher and higher statin dosages over the years as target levels for serum cholesterol have been progressively lowered. Adding to cholesterol's innocence is its vital role in the body - mediator of synaptic transmissions, precursor of vital hormones and the most abundant biochemical in our brains. The TNT trial (Treatment to New Targets) compared the effects of atorvastatin given at a dose of either 80 mg/d or 10 mg/d. We comply with the HONcode standard for trustworthy health information -, Hyperlipoproteinemia Type IIa (Elevated LDL), Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL), Hyperlipoproteinemia Type III (Elevated beta-VLDL + IDL), Hyperlipoproteinemia Type IV (Elevated VLDL), Heterozygous Familial Hypercholesterolemia. Note that no personal medical questions of any kind can or will be answered. Adults—At first, 10 or 20 milligrams (mg) once a day. 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